Secreted frizzled-related protein 5 serum levels in human periodontitis-A nested case-control study.

TitelSecreted frizzled-related protein 5 serum levels in human periodontitis-A nested case-control study.
MedientypJournal Article
Jahr der Veröffentlichung2019
AutorenSchulz J, Knappe C, Graetz C, Mewes L, Türk K, Black AK, Lieb W, Schäfer AS, El-Sayed KMFawzy, Dörfer CE, Schreiber S, Laudes M, Schulte DM
JournalJ Clin Periodontol
Volume46
Ausgabe5
Pagination522-528
Datum der Veröffentlichung2019 May
ISSN1600-051X
Zusammenfassung

<p><b>AIM: </b>Recombinant secreted frizzled-related protein 5 (sFRP5) improved periodontal status in mice. Thus, this study aimed to investigate this finding in human periodontitis using an epidemiological approach.</p><p><b>MATERIALS AND METHODS: </b>sFRP5 and wnt5a concentrations were determined in human serum from the Food Chain Plus cohort using ELISAs. A total of 128 patients with periodontitis and tooth loss and 245 patients with periodontitis without tooth loss were compared to 373 sex-, smoker-, age- and BMI-matched individuals in a nested case-control design.</p><p><b>RESULTS: </b>Systemic sFRP5 serum levels were significantly lower in patients with periodontitis and tooth loss (2.5 [0.0-10.4] ng/ml, median [IQR]) compared to patients with periodontitis without tooth loss (6.0 [2.5-15.8] ng/ml, median [IQR], p = 0.04] and matched controls (7.0 [2.5-18.3] ng/ml, median [IQR], p = 0.02). No significant differences in sFRP5 serum levels were found among patients with periodontitis without tooth loss (6.0 [2.5-15.8] ng/ml, median [IQR]) and controls (3.1 [0.0-10.6] ng/ml, median [IQR], p = 0.06).</p><p><b>CONCLUSIONS: </b>sFRP5 might serve as a novel biomarker for periodontitis severity. Modulating the inflammatory background of severe forms of periodontitis, in the time of precision medicine, needs to be revealed in further studies.</p>

DOI10.1111/jcpe.13087
Alternate JournalJ. Clin. Periodontol.
PubMed ID30762911
Grant List01ZX1306A / / German Federal Ministry of Education and Research (BMBF) /
0315540C / / cluster FoCus /