|Titel||Association between the dietary inflammatory index and all-cause mortality in colorectal cancer long-term survivors.|
|Jahr der Veröffentlichung||2018|
|Autoren||Ratjen I, Shivappa N, Schafmayer C, Burmeister G, Nöthlings U, Hampe J, Hébert JR, Lieb W, Schlesinger S|
|Journal||Int J Cancer|
|Datum der Veröffentlichung||2018 Oct 10|
Pro-inflammatory dietary factors have been shown to be associated with the incidence of a range of cancers. However, there are many fewer studies on the association between the inflammatory potential of diet and survival after cancer diagnosis. We examined the association between post-diagnosis dietary inflammatory index (DII®) scores and all-cause mortality in long-term survivors of colorectal cancer (CRC). DII scores were calculated from dietary data of 1404 CRC survivors collected at a median of 6 years after CRC diagnosis. Using multivariable-adjusted Cox proportional hazards regression models, hazard ratios (HR) and 95% confidence intervals (CI) were estimated for the association of DII scores, modeled continuous and in quartiles, with all-cause mortality. After a median follow-up time of 7 years (after dietary assessment), 204 study participants had died. Overall, in the fully adjusted model there was a suggestion of a positive association between DII score and all-cause mortality (HR : 1.36; 95% CI: 0.88-2.09 and HR : 1.08; 95% CI: 0.97-1.20). However, in subgroup analyses, we found significant differences in individuals with metastatic disease (HR : 1.34; 95% CI: 1.07-1.67) and the absence of stoma (HR : 1.15; 95% CI: 1.02-1.29). Overall, the post-diagnosis DII was not statistically significantly associated with all-cause mortality in CRC long-term survivors; however, there was suggestive evidence of an association in select subgroups. This article is protected by copyright. All rights reserved.
|Alternate Journal||Int. J. Cancer|