Small dense LDL cholesterol in human subjects with different chronic inflammatory diseases.

TitelSmall dense LDL cholesterol in human subjects with different chronic inflammatory diseases.
MedientypJournal Article
Jahr der Veröffentlichung2018
AutorenSchulte DM, Paulsen K, Türk K, Brandt B, Freitag-Wolf S, Hagen I, Zeuner R, Schröder JO, Lieb W, Franke A, Nikolaus S, Mrowietz U, Gerdes S, Schreiber S, Laudes M
JournalNutr Metab Cardiovasc Dis
Datum der Veröffentlichung2018 11
SchlüsselwörterAdult, Aged, Anti-Inflammatory Agents, Atherosclerosis, Biomarkers, Case-Control Studies, Cholesterol, LDL, Chronic Disease, Female, Germany, Humans, Inflammatory Bowel Diseases, Male, Middle Aged, Particle Size, Phenotype, Prospective Studies, Psoriasis, Receptors, Interleukin-6, Risk Factors, Spondylitis, Ankylosing, Time Factors, Treatment Outcome, Tumor Necrosis Factor-alpha

<p><b>BACKGROUND AND AIMS: </b>Chronic inflammatory diseases (CID) are associated with a profound increase in cardiovascular (CV) risk resulting in reduced life expectancy. However, LDL-cholesterol is reported to be low in CID patients which is referred to as the "LDL paradoxon". The aim of the present study was to investigate whether LDL-particles in CID exhibit an increased content of the highly atherogenic small-dense LDL subfraction (sdLDL).</p><p><b>METHODS AND RESULTS: </b>In this prospective, single center, observational study we enrolled 141 patients with CID (RA n = 59, inflammatory bowel disease (IBD) n = 35, ankylosing spondylitis (SpA) n = 25, Psoriasis n = 22) in 2011 through 2013 to evaluate sdLDL levels before as well as 6 and 26 weeks after initiation of different anti-cytokine therapies (anti-TNFα, anti-IL-6R antibodies). sdLDL levels were compared to 141 healthy individuals in a case control design. Compared to healthy controls, all CID patients displayed a significantly higher sdLDL content within the LDL cholesterol fraction: RA 35.0 ± 9.2% (p < 0.001), SpA 42.5 ± 10.5% (p < 0.001), IBD 37.5 ± 7.1% (p < 0.001), Psoriasis 33.6 ± 4.6% (p < 0.01). Furthermore, the sdLDL/LDL ratio was significantly higher in male compared to female RA subjects (p < 0.05). Neither anti-TNFα nor anti-IL6R medication altered sdLDL levels despite a significant improvement of disease activity.</p><p><b>CONCLUSION: </b>In several different chronic inflammatory disease entities, LDL-cholesterol is shifted toward a pro-atherogenic phenotype due to an increased sdLDL content which might in part explain the LDL paradoxon. Since premature CV disease is a major burden of affected patients, specifically targeting lipid metabolism should be considered routinely in clinical patient care.</p><p><b>CLINICAL TRIALS: </b>Registration at German Clinical Trial Register (DRKS): DRKS00005285.</p>

Alternate JournalNutr Metab Cardiovasc Dis
PubMed ID30143407