On a Western diet, APOE ε4 is associated with low innate immune sensing, but not APOE ε3.

TitelOn a Western diet, APOE ε4 is associated with low innate immune sensing, but not APOE ε3.
MedientypJournal Article
Jahr der Veröffentlichung2018
AutorenDose J, Schloesser A, Torres GG, Venkatesh G, Häsler R, Flachsbart F, Lieb W, Nebel A, Rimbach G, Huebbe P
JournalJ Allergy Clin Immunol
Datum der Veröffentlichung2018 Jun 18
ISSN1097-6825
Zusammenfassung

Under conditions reflecting the Western lifestyle, APOE ε4 vs. APOE ε3 may be associated with a lower expression of markers important in innate immune activation. The results encourage further investigations into the role of the APOE genotype in metabolic diseases associated with chronic inflammation.

DOI10.1016/j.jaci.2018.05.033
Alternate JournalJ. Allergy Clin. Immunol.
PubMed ID29928926