Dietary pattern associated with selenoprotein P and MRI-derived body fat volumes, liver signal intensity, and metabolic disorders.

TitelDietary pattern associated with selenoprotein P and MRI-derived body fat volumes, liver signal intensity, and metabolic disorders.
MedientypJournal Article
Jahr der Veröffentlichung2019
Autorendi Giuseppe R, Plachta-Danielzik S, Koch M, Nöthlings U, Schlesinger S, Borggrefe J, Both M, Müller H-P, Kassubek J, Jacobs G, Lieb W
JournalEur J Nutr
Volume58
Ausgabe3
Pagination1067-1079
Datum der Veröffentlichung2019 Apr
ISSN1436-6215
Zusammenfassung

<p><b>PURPOSE: </b>The association of complex dietary patterns with circulating selenoprotein P (SELENOP) levels in humans is unknown. In a general population sample, we aimed to identify a dietary pattern explaining inter-individual variation in circulating SELENOP concentrations and to study this pattern in relation to prevalent diabetes, metabolic syndrome (MetS), MRI-determined total volumes of visceral (VAT) and subcutaneous (SAT) abdominal adipose tissue, and liver signal intensity/fatty liver disease.</p><p><b>METHODS: </b>In this cross-sectional study, serum SELENOP levels were measured in 853 individuals. In a subsample of 553 participants, whole-body MRI was performed to assess body fat distribution and liver fat. Dietary intake was assessed by a self-administered food frequency questionnaire and the dietary pattern identified using reduced-rank regression (RRR). Multivariable linear and logistic regressions were used to investigate associations between dietary pattern score and metabolic traits.</p><p><b>RESULTS: </b>Characterized by high intake of fruit, vegetables and antioxidant beverages, the RRR-derived dietary pattern displayed inverse associations with VAT, SAT, MetS, and prevalent diabetes in multivariable-adjusted restricted cubic splines. Each unit increase in dietary pattern score was associated with 31% higher SELENOP levels, 12% lower VAT (95% CI: - 19%; - 5%), 13% (95% CI: - 20%; - 6%) lower SAT values and 46% (95% CI: 27%; 60%) and 53% (95% CI: 22%; 72%) lower odds of having MetS or diabetes, respectively. No meaningful relations were observed between the dietary pattern and liver traits.</p><p><b>CONCLUSIONS: </b>Our observations propose diet-related regulation in SELENOP levels and that the identified dietary pattern is inversely related to VAT, SAT, MetS, and prevalent diabetes.</p>

DOI10.1007/s00394-018-1624-2
Alternate JournalEur J Nutr
PubMed ID29445913
Grant List01EY1103 / / German Federal Ministry of Education and Research /
EXC306/2 / / Deutsche Forschungsgemeinschaft Excellence Cluster "Inflammation at Interfaces" /