Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci.

TitelApplication of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci.
MedientypJournal Article
Jahr der Veröffentlichung2018
AutorenRühlemann MC, Degenhardt F, Thingholm LB, Wang J, Skiecevičienė J, Rausch P, Hov JR, Lieb W, Karlsen TH, Laudes M, Baines JF, Heinsen F-A, Franke A
JournalGut Microbes
Volume9
Ausgabe1
Pagination68-75
Datum der Veröffentlichung2018 01 02
ISSN1949-0984
SchlüsselwörterAntigens, Nuclear, Bacteria, Biodiversity, Gastrointestinal Microbiome, Genetic Loci, Genetic Variation, Genome-Wide Association Study, Host-Pathogen Interactions, Humans, Immunity, Models, Statistical, OX40 Ligand, Reproducibility of Results, RNA-Binding Proteins, Sodium-Hydrogen Exchangers, Transcription Factors
Zusammenfassung

<p>Factors shaping the human intestinal microbiota range from environmental influences, like smoking and exercise, over dietary patterns and disease to the host's genetic variation. Recently, we could show in a microbiome genome-wide association study (mGWAS) targeting genetic variation influencing the β diversity of gut microbial communities, that approximately 10% of the overall gut microbiome variation can be explained by host genetics. Here, we report on the application of a new method for genotype-β-diversity association testing, the distance-based F (DBF) test. With this we identified 4 loci with genome-wide significant associations, harboring the genes CBEP4, SLC9A8, TNFSF4, and SP140, respectively. Our findings highlight the utility of the high-performance DBF test in β diversity GWAS and emphasize the important role of host genetics and immunity in shaping the human intestinal microbiota.</p>

DOI10.1080/19490976.2017.1356979
Alternate JournalGut Microbes
PubMed ID28816579
PubMed Central IDPMC5939986