Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

TitelGenetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.
MedientypJournal Article
Jahr der Veröffentlichung2018
AutorenAlberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KMuri, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J, Eksteen B, Ellinghaus D, Farkkila M, Festen EAM, Floreani A, Franceschet I, Gotthardt DNils, Hirschfield GM, van Hoek B, Holm K, Hohenester S, Hov JRoksund, Imhann F, Invernizzi P, Juran BD, Lenzen H, Lieb W, Liu JZ, Marschall H-U, Marzioni M, Melum E, Milkiewicz P, Müller T, Pares A, Rupp C, Rust C, Sandford RN, Schramm C, Schreiber S, Schrumpf E, Silverberg MS, Srivastava B, Sterneck M, Teufel A, Vallier L, Verheij J, Vila AVich, de Vries B, Zachou K, Chapman RW, Manns MP, Pinzani M, Rushbrook SM, Lazaridis KN, Franke A, Anderson CA, Karlsen TH, Ponsioen CY, Weersma RK
Corporate AuthorsInternational PSC Study Group, The UK PSC Consortium
JournalGut
Volume67
Ausgabe8
Pagination1517-1524
Datum der Veröffentlichung2018 08
ISSN1468-3288
SchlüsselwörterAdult, Cholangitis, Sclerosing, Cohort Studies, Disease Progression, Female, Humans, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Proportional Hazards Models, Thrombospondins
Zusammenfassung

<p><b>OBJECTIVE: </b>Primary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct disease of largely unknown aetiology often leading to liver transplantation or death. Little is known about the genetic contribution to the severity and progression of PSC. The aim of this study is to identify genetic variants associated with PSC disease progression and development of complications.</p><p><b>DESIGN: </b>We collected standardised PSC subphenotypes in a large cohort of 3402 patients with PSC. After quality control, we combined 130 422 single nucleotide polymorphisms of all patients-obtained using the Illumina immunochip-with their disease subphenotypes. Using logistic regression and Cox proportional hazards models, we identified genetic variants associated with binary and time-to-event PSC subphenotypes.</p><p><b>RESULTS: </b>We identified genetic variant rs853974 to be associated with liver transplant-free survival (p=6.07×10). Kaplan-Meier survival analysis showed a 50.9% (95% CI 41.5% to 59.5%) transplant-free survival for homozygous AA allele carriers of rs853974 compared with 72.8% (95% CI 69.6% to 75.7%) for GG carriers at 10 years after PSC diagnosis. For the candidate gene in the region, , we demonstrated expression in key liver-resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.</p><p><b>CONCLUSION: </b>We present a large international PSC cohort, and report genetic loci associated with PSC disease progression. For liver transplant-free survival, we identified a genome-wide significant signal and demonstrated expression of the candidate gene in key liver-resident effector cells. This warrants further assessments of the role of this potential key PSC modifier gene.</p>

DOI10.1136/gutjnl-2016-313598
Alternate JournalGut
PubMed ID28779025
PubMed Central IDPMC5797498
Grant ListMC_PC_12009 / / Medical Research Council / United Kingdom
MR/L016761/1 / / Medical Research Council / United Kingdom
R01 DK084960 / DK / NIDDK NIH HHS / United States