Omentin-1 and risk of myocardial infarction and stroke: Results from the EPIC-Potsdam cohort study.

TitelOmentin-1 and risk of myocardial infarction and stroke: Results from the EPIC-Potsdam cohort study.
MedientypJournal Article
Jahr der Veröffentlichung2016
AutorenMenzel J, di Giuseppe R, Biemann R, Wittenbecher C, Aleksandrova K, Pischon T, Fritsche A, Schulze MB, Boeing H, Isermann B, Weikert C
JournalAtherosclerosis
Volume251
Pagination415-421
Datum der Veröffentlichung2016 08
ISSN1879-1484
SchlüsselwörterAdipokines, Adiponectin, C-Reactive Protein, Cohort Studies, Cytokines, Female, GPI-Linked Proteins, Humans, Lectins, Male, Middle Aged, Multivariate Analysis, Myocardial Infarction, Risk Factors, Stroke, Triglycerides, Waist Circumference
Zusammenfassung

<p><b>BACKGROUND AND AIMS: </b>The recently identified adipokine omentin-1 is inversely associated with body fatness, metabolic syndrome and cardiovascular disease (CVD) in cross-sectional analyses. However, prospective data on the association between plasma omentin-1 levels and future risk of CVD are lacking. The aim of the study was to investigate the relationship between omentin-1 and incident myocardial infarction (MI) and stroke.</p><p><b>METHODS: </b>We conducted a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort comprising a subsample of 2084 participants, including 50 CVD cases and 350 external incident CVD cases (mean follow-up of 8.2 ± 1.6 years). Prentice modified Cox regression adjusted for established CVD risk factors was used to estimate associations between omentin-1 and risk of MI and stroke, interactions were tested with cross-product terms.</p><p><b>RESULTS: </b>After multivariable adjustment, omentin-1 was not significantly associated with risk of MI (HR per doubling omentin-1:1.17; 95%-CI:0.79-1.72; p = 0.43), but with higher risk of stroke (HR per doubling omentin-1:2.22; 95%-CI:1.52-3.22; p < 0.0001). In subgroup analyses, associations between omentin-1 and stroke risk were generally stronger in lower versus higher CVD risk groups. For example, risk of stroke was stronger in participants without metabolic syndrome (HR per doubling omentin-1:2.58; 95%-CI:1.64-4.07; p < 0.0001) compared to those with metabolic syndrome (HR per doubling omentin-1:1.21; 95%-CI:0.59-2.50; p = 0.60) (p for interaction = 0.05). Similar interactions were observed when participants were classified in low or high risk groups according to waist circumference, triglyceride, hsCRP or adiponectin levels.</p><p><b>CONCLUSIONS: </b>Omentin-1 concentrations may be related to increased stroke risk. This association is stronger in metabolically healthy individuals.</p>

DOI10.1016/j.atherosclerosis.2016.06.003
Alternate JournalAtherosclerosis
PubMed ID27298015